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Post-Doc Research Associate - Crona Lab
University of North Carolina in Chapel Hill, North Carolina
Date Posted 10/30/2021
Admin-Laboratory and Research
Employment Type FullTime
Application Deadline Open until filled

Posting Information
Department SOP-DPET - 452200
Posting Open Date 10/28/2021
Application Deadline 01/03/2022
Open Until Filled No
Position Type Postdoctoral Scholar
Position Title Post-Doc Research Associate - Crona Lab
Vacancy ID PDS003255
Full-time/Part-time Full-Time Temporary
Hours per week 40
Work Location Chapel Hill, NC
Position Location North Carolina, US
Hiring Range $53,760 - $56,712 (dependent on qualifications)
Proposed Start Date
Estimated Duration of Appointment 12 Months

Primary Purpose of Organizational Unit
The UNC Eshelman School of Pharmacy (www.pharmacy.unc.edu) is one of five health science schools (Pharmacy, Nursing, Dentistry, Public Health, Medicine) at the University of North Carolina at Chapel Hill and is one of the oldest health science academic programs at Chapel Hill. The School teaches approximately 600 PharmD students, 100 PhD students, and 20 Master’s students. The School has built a reputation for its continued pursuit of excellence, rigorous education and training programs, cutting-edge multidisciplinary research, progressive pharmacy practices, efficient business operations, and its outstanding faculty, staff, and students. The School was named the number one School of Pharmacy in the U.S. by the U.S. News and World Report. The School has experienced unprecedented growth and success and continues to strategically position itself for sustained impact, as articulated in the School’s Strategic Plan (https://pharmacy.unc.edu/about/ospa/strategic-plan/)
Our vision is to be the preeminent school of pharmacy where leaders in practice, education, and research are developed and nurtured. We are Advancing Medicine for Life through innovation and collaboration in pharmacy practice, education, research, and public service.
The School’s vision is grounded in our aspiration to be a diverse and inclusive community of people who accelerate new thinking and ideas in education, research, and practice that have a positive impact on human health worldwide. We envision a school that reflects, in all its dimensions, the population it serves.
Position Summary
A postdoctoral research position is available immediately to support funding from the Department of Defense to develop a first-in-class antagonist of the methyl-lysine reader protein MPP8 in preclinical models of treatment-resistant metastatic prostate cancer. MPP8 been shown to play a key role in the silencing of E-cadherin, a central modulator of epithelial to mesenchymal transition, metastatic spread and transition from treatment-resistant metastatic castration resistant prostate cancer to the lethal neuroendocrine prostate cancer. Utilizing structure-based design, we have discovered a lead MPP8 antagonist, which potently blocks H3K9me3 recognition by the MPP8 chromodomain, and are actively recruiting a post-doctoral research associate to lead further drug development initiatives.
The laboratory of Dr. Daniel Crona in the UNC Eshelman School of Pharmacy’s Division of Pharmacotherapy and Experimental Therapeutics (DPET) is positioned at the interface between the research laboratory and the clinic.  Our research is focused on a functional genomics paradigm that helps reveal molecular mechanisms that underlie the interplay between patient genotype, phenotype, and epigenetics. Molecular mechanistic information is then integrated with clinical pharmacology (e.g., pharmacokinetics and pharmacodynamics) to optimize drug selection and dosing for hematology/oncology patients. In the laboratory setting, we utilize new chemically mediated tools modulate changes in chromatin structure/function and gene expression in mammalian cells and animal models of human cancer. We also work with investigators from the UNC Center for Integrative Chemical Biology and Drug Discovery to develop inhibitors of chromatin regulatory enzymes with the goal of making a substantive impact on the treatment of cancer. 
Minimum Education and Experience Requirements
PhD in Biological Sciences, Pharmaceutical Sciences, Chemical Biology, or related field
Required Qualifications, Competencies, and Experience
Excellent oral and written communication skills, the ability to work independently as well as a member of an inter-disciplinary team, and prior experience with primary cell culture and molecular biology techniques are essential.
Preferred Qualifications, Competencies, and Experience
A strong academic record of accomplishment with a history of meaningful publications is preferred. Expertise in gene editing techniques (e.g., CRISPR/Cas), molecular biology, and/or epigenetics techniques, and work with cancer xenograft or GEM models will be considered an advantage.
Special Physical/Mental Requirements
Special Instructions
For information on UNC Postdoctoral Benefits and Services click here
Quick Link https://unc.peopleadmin.com/postings/214434

Department Contact Name and Title Victoria Fleming, HR Concultant
Department Contact Telephone or Email parnellv@email.unc.edu
Postdoctoral Affairs Contact Information

If you experience any problems accessing the system or have questions about the application process, please contact the University’s Equal Employment Opportunity office at (919) 966-3576 or send an email to equalopportunity@unc.edu.

Please note: The Equal Employment Opportunity office will not be able to provide specific updates regarding position or application status.

Equal Opportunity Employer Statement
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.

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